There have been cracking goals, crunching tackles and some moments of madness. They have played each other 103 times since 1920 and Albion have won 40, drew 26 and lost 37. Test your knowledge with our 15 question quiz. Scroll down and click through to the to end where the answers will be revealed.
13. Glenn Murray
What year did the striker make the controversial switch from Brighton to Selhurst Park?
14. Palace 5-0 Brighton
October 26, 2002 Selhurst Park. Palace smashed five past Brighton that day in division one. But who scored a hat-trick for Palace?
15. Brighton 3-0 Palace
March 17, 2013 Amex Stadium. Leo Ulloa scored a brace in this high-noon showdown but which Spaniard bagged the other that day.
16. Answers
1: Florin Andone, 2: Luka Milivojevic, 3: Mullery threw coins, shouting, Youre not worth that, Palace, 4: Tomasz Kuszczak, 5: Lewis Dunk, Dale Stephens and Glenn Murray, 6: VAR 7: Izquierdo, 8: Leonardo Ulloa, 9: Paul McShane, 10: Ashley Barnes, 11: Jordan Ayew, 12: Trossard (Albion), Benteke (Palace), 13: 2011, 14: Andrew Johnson, 15: David Lopez.