An eye-witness said the incident happened in Carnegie Road shortly before 7am.
Ambulance, police and fire crews attending the incident, according to an eye-witness.
West Sussex Fire and Rescue Service has been contacted for more information.
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1. House fire in Carnegie Road, Worthing
House fire in Carnegie Road, Worthing Photo: EDDIE MITCHELL
2. House fire in Carnegie Road, Worthing
House fire in Carnegie Road, Worthing Photo: EDDIE MITCHELL
3. House fire in Carnegie Road, Worthing
House fire in Carnegie Road, Worthing Photo: EDDIE MITCHELL
4. House fire in Carnegie Road, Worthing
House fire in Carnegie Road, Worthing Photo: EDDIE MITCHELL