A 29-year-old man had part of his ear bitten off when he and a friend were attacked by a large group of men in the town centre in the early hours of Saturday morning.
Police were called to Terminus Road at 3.19am where the two Eastbourne men were found injured.
A 22-year-old man had a cut across the bridge of his nose and the other, 29, had part of his ear bitten off.
A spokesperson at Sussex Police said, “Both men had blood on their faces and clothing. No witnesses have come forward.”
Detectives are now urging anyone with any information or who may have witnessed the attack to contact them.
The spokesperson said, “We would ask people to phone Sussex Police on 101 or email firstname.lastname@example.org, quoting serial 0215 of 29/3. Alternatively, please contact the independent charity Crrimestoppers free and anonymously on 0800 555 111.”