Two people were taken to hospital after a three-car collision outside the Hillier Garden Centre between Hailsham and Stone Cross on Thursday afternoon.
Emergency services were called to the B2104 Hailsham Road at around 4.10pm on Thursday, January 2 after a red Daewoo, a silver Mercedes Benz and a red Honda collided.
East Sussex Fire and Rescue Service attended the scene, with crews from Eastbourne and Pevensey releasing two people from their vehicles.
The driver of the Mercedes Benz, a 53-year-old woman, and the driver of the Honda, a 53-year-old man, were taken to the Royal Sussex County Hospital, Brighton, for treatment to injuries that were not thought to be life-threatening.
A 27-year-old woman driving the Daewoo and a 60-year-old man who was a passenger in the Mercedes Benz were not injured.
The road was closed for almost two hours while emergency services were at the scene.
Anyone who saw the collision is asked to phone Sussex Police on 101 or email: firstname.lastname@example.org, quoting serial 0829 of 2/1.